Detection of amino groups on resinNH2-peptide-resin23ContentContent： Fires and explosions have caused and are still causing Fires and explosions have caused and are still causing serious serious damages to the society. The goal of our research is damages to the society. The goal of our research is to establish a to establish a reliable method to assess the consequences of reliable method to assess the consequences of each potential fire or each potential fire or explosion scenario. In particular, explosion scenario. In particular, phenomena that may significantly phenomena that may significantly increase the damage of a increase the damage of a fire or explosion, such as fire whirl, surface fire or explosion, such as fire whirl, surface flash, and large-flash, and large-scale explosion, are studied through scale-model scale explosion, are studied through scale-model experiments, numerical simulations, and theoretical analyses.experiments, numerical simulations, and theoretical analyses.Appealing point：Special objectives We also study thermofluid phenomena other than fire & explosion.Yamagata UniversityGraduate School of Science and Engineering Research Interest ：CombustionYamagata University Graduate School of Science and Engineering E-mail ：kuwana@yz.yamagata-u.ac.jpResearch InterestTel ：+81-238-26-3167CombustionFax：+81-238-26-3414E-mail ・ kuwana@yz.yamagata-u.ac.jpTel ・ +81-238-26-3167Fax ・ +81-238-26-3414HP ：http://acebe.yz.yamagata-u.ac.jp/HP・http://acebe.yz.yamagata-u.ac.jp/BerberineRalstoninBurkholdineEffective safety managementA fire whirl is generated by the interaction between a lateral flow and a buoyant upward flow from a fire. Once a fire whirl is generated, the burning rate increases, signifying the damage.Fast flame spread over the surface of a napped fabric is called surface flash. When surface flash occurs, the flame spread velocity increases 10-100 times.sourcefordrugs,pseudo-peptidesChemical BiologyTo prevent accidents, it is important to assess the risk level of each To prevent accidents, it is important to assess the risk material or operation and to take measures to reduce the risk level if level of each material or operation and to take measures to it is too high to be accepted. Scientific understanding of phenomena reduce the risk level if it is too high to be accepted. associated with potential accidents is essential for accurate risk Scientific understanding of phenomena associated with assessment.potential accidents is essential for accurate risk assessment.We also study thermofluidphenomena other than fire & explosion.Content：ContentPeptidylnaturalproductscontainingunusualaminoacidsare Peptidyl natural products containing unusual amino acids importantandfunctionalare important source for drugs, pseudo-peptides and molecules.Theseuniquestructuresarealsoattractiveinthefunctional molecules. These unique structures are also syntheticviewpoint.Ourgrouphavebeenstudiedondrugdiscoveryattractive in the synthetic viewpoint. Our group have been formembraneproteins,cysteineproteaseandamyloidpeptide.studied on drug discovery for membrane proteins, cysteine A.DrugdiscoveryagainstchemokinereceptorCCR5usingprotease and amyloid peptide. fluorescentTAK779fortheanalysisofinteractionwithproteinA. Drug discovery against chemokine receptor CCR5 using inhibitors.fluorescent TAK779 for the analysis of interaction with B.Structureactivityrelationshipstudyoftheamyloidβaggregationprotein inhibitors.B. Structure activity relationship study of the amyloid β inhibitorsusingcurcuminoidsandberberine.aggregation inhibitors using curcuminoids and berberine.C.Synthesisandevaluationofnon-peptidylinhibitorsagainstmainC. Synthesis and evaluation of non-peptidyl inhibitors against 3CLproteaseforthecoronavirus.main 3CL protease for the corona virus. D.Detectionofaminogroupsandthiolfunctionalities.ChemicalD. Detection of amino groups and thiol functionalities. ligationoflongsequencepeptides.Investigationofanti-microbialChemical ligation of long sequence peptides. Investigation of peptides.anti-microbial peptides.Appealingpoint：MyresearchinterestsarechemicalsynthesisofpeptidesonsolidSpecial objectivessupportandstereoselectivesynthesisofbio-activeorganicmolecules My research interests are chemical synthesis of peptides fordrugdiscovery.on solid support and stereoselective synthesis of bio-active organic molecules for drug discovery.Yamagata UniversityGraduate School of Science and Engineering Research Interest ：Medicinal Chemistry, Yamagata University Graduate School of Science and Engineering Research InterestE-mail ：konno@yz.yamagata-u.ac.jpMedicinal Chemistry, Chemical BiologyTel ：+81-238-26-3131E-mail ・ konno@yz.yamagata-u.ac.jpFax：+81-238-26-3131Tel ・ +81-238-26-3131Fax ・ +81-238-26-3131HP・http://bioorg.yz.yamagata-u.ac.jpHP ：http://bioorg.yz.yamagata-u.ac.jpFire whirlSurface flashEffective safety managementScience of fire & explosionScience of fire & explosionFire, Explosion & Safety EngineeringDrug Discovery for Membrane Proteins, Proteases and Amyloid peptidesDrug Discovery for Membrane Proteins, Proteases and Amyloid peptidesProfessor Hiroyuki KonnoProfessor Kazunori KuwanaFire, Explosion & Safety EngineeringProfessor Kazunori KuwanaProfessorHiroyuki Konno
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