2020-2022 YAMAGATA UNIVERSITY Research Seeds Collection
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15IllustrationContent:ContentProf.Narumigroupstudiesapolymerizationsystemthatenablesthe Prof. Narumi group studies a polymerization system that ring-expansion“vinyl”polymerizationasafundamentalresearchinenables the ring-expansion “vinyl” polymerization as a thefieldofpolymersynthesis.fundamental research in the field of polymer synthesis.Also,avarietyofphotoactivecompoundsaresynthesizedinthisgroup,whichshowaccumulationabilitiestowardtumorcellsin Also, a variety of photoactive compounds are synthesized ordertodevelopadvancedphotosensitizersforthephotodynamicin this group, which show accumulation abilities toward therapy(PDT).tumor cells in order to develop advanced photosensitizers for the photodynamic therapy (PDT).Appealingpoint:Polysaccharidesare“inexhaustibleorganicrawmaterials”and/orSpecial objectives“polymersshowingbiodegradability”andthustheirutilizationsare Polysaccharides are “inexhaustible organic raw materials” mostimportant.Ourgroupaimstoprovideadvancedandsafeand/or “polymers showing biodegradability” and thus their polymetric/organicmaterialsbasedonsyntheticchemistryusingutilizations are most important. Our group aims to provide polysaccharides.advanced and safe polymetric/organic materials based on synthetic chemistry using polysaccharides.Yamagata University,Graduate School of Organic Materials Science Research Interest :Polymer synthesisE-mail :narumi@yz.yamagata-u.ac.jpYamagata University Graduate School of Organic Materials Science Tel :+81-238-26-3829Research InterestPolymer synthesisHP :http://narumi-lab.yz.yamagata-u.ac.jpE-mail ・ narumi@yz.yamagata-u.ac.jpTel ・ +81-238-26-3829HP・http://narumi-lab.yz.yamagata-u.ac.jpContentContent:Non-invasivediagnosticsensorsforbiomarkersaregenerally Non-invasive diagnostic sensors for biomarkers are requiredasanalternativetoblood-baseddiagnosesforthenextgenerally required as an alternative to blood-based generationofadvancedhealthcare.Wehavedevelopedtheorganicdiagnoses for the next generation of advanced healthcare. We have developed the organic transistor-based biosensors transistor-basedbiosensorstoquantifythesebiomarkersfromsweatto quantify these biomarkers from sweat and saliva. This andsaliva.Thistypeofsensorarepromisingdevicesbecausetheirtype of sensor are promising devices because their output outputelectricalsignalsarehighlyamplifiedthatisenoughtodetectelectrical signals are highly amplified that is enough to lowconcentrationofbiomarkersintheexternally-excretedbodilydetect low concentration of biomarkers in the externally-fluids.Ourfinalgoalisrealizationofthesmartpersonalizedexcreted bodily fluids. Our final goal is realization of the healthcaredevicefornon-invasiveandreliablemonitoringofhumansmart personalized healthcare device for non-invasive and health.reliable monitoring of human health.Anotherresearchisapplicationoftheseelectrochemicalbiodevice Another research is application of these electrochemical toinvitrobacteria-andcell-basedbioassay.Ourfinalgoalistobiodevice to in vitro bacteria- and cell-based bioassay. Our measureandregulatephysiologicalfunctionsofthebacteriaandfinal goal is to measure and regulate physiological functions cellstorealizethesmartmedicaldevices.of the bacteria and cells to realize the smart medical devices.Appealingpoint:WeareconductingR&Dthroughindustry-academiacollaborationaimingatvariousapplicationsofsensors(currentlymedicineandagriculture). We are conducting R&D through industry-academia collaboration aiming at various applications of sensors (currently medicine and agriculture).Yamagata UniversityGraduate School of Science and Engineering Research Interest :BioelectrochemistryYamagata University Graduate School of Science and Engineering E-mail :nagamine@yz.yamagata-u.ac.jpResearch InterestTel :+81-238-26-3227BioelectrochemistryFax:+81-238-26-3788E-mail ・ nagamine@yz.yamagata-u.ac.jpTel ・ +81-238-26-3227HP :http://nagamine-lab.yz.yamagata-u.ac.jpFax ・ +81-238-26-3788HP・http://nagamine-lab.yz.yamagata-u.ac.jpSpecial objectivesDevelopment of the electrochemical biodevicesAssociate Professor Kuniaki Nagamine  Associate ProfessorKuniakiNagamineDevelopment of the electrochemical biodevicesOrganic transistor-based biosensorPrecision polymer synthesis + Photoactivation + BioconjugationPrecision polymer synthesis + Photoactivation + BioconjugationThebiodevicesfor(1)non-invasivequantificationofbiomarkersinhumanbodilyfluids(sweat,saliva,etc..),and(2)invitrobacteria-andcell-basedbioassay.PDT photosensitizerMacrocyclic polymer synthesisAssociate ProfessorAtsushi Narumi Associate Professor Atsushi Narumi

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