・Cellular respiration measurement system based on SECM・Cell screening system based on mitochondrial respiration 21Illustration: Nano-and micro-structures using atmospheric pressure plasmas1) Surface structures obtained by thermal plasmas2) Surface structures obtained by cold plasmas3) An example of properties of the surface microstructureSuper hydrophilicIllustrationScanning Electrochemical Microscopy (SECM) systemEmbryo MitochondriaOCT systemDoppler OCT system for non-invasive imaging of ovarySubjects:・Development of diagnoticsystem for embryo and oocytequality using SECM.・Development of evaluation system for gametes and stem cells quality using OCT.Super water repellent3DimagingofoocytesYamagata University Graduate School of Science and Engineering E-mail ：aita@yz.yamagata-u.ac.jpResearch InterestTel ：+81-238-26-3145Chemical Reaction EngineeringFax：+81-238-26-3145E-mail ・ aita@yz.yamagata-u.ac.jp Tel ・ +81-238-26-3145Fax ・ +81-238-26-3145Yamagata UniversityGraduate School of Science and Engineering Research Interest ：Chemical Reaction EngineeringBiomedical EngineeringPlease put your photograph. ContentContent：・Atmosphricpressure plasma process has advantages such as no ・Atmosphric pressure plasma process has advantages such requirement of expensive vacuum equipment and easy operation as no requirement of expensive vacuum equipment and as compared with ordinary plasma process under reduced pressure.easy operation as compared with ordinary plasma process ・In this research, various nano-and micro-structures are formed on under reduced pressure.glass and metal substrates using micro thermal and cold plasmas・In this research, various nano- and micro-structures are ・The products that form the fine structures are metal oxides and formed on glass and metal substrates using micro thermal organic substances.and cold plasmas.・With thermal plasma, fine products can be deposited on glass or ・The products that form the fine structures are metal oxides metal surfaces, and with cold plasma, fine products can also be and organic substances.deposited on heat-sensitive materials.・With thermal plasma, fine products can be deposited on ・It can be expected to add functionality derived from nano-and glass or metal surfaces, and with cold plasma, fine micro-structures.products can also be deposited on heat-sensitive materials.・It can be expected to add functionality derived from nano- and micro-structures.Appealing point：If the research content matches or is related to what the company Special objectivesrequires, I will actively engage in industry-academia collaboration. Our strength is that we can make equipment in our laboratory as If the research content matches or is related to what the needed.company requires, I will actively engage in industry-academia collaboration. Our strength is that we can make equipment in our laboratory as needed.ContentContent：The goals of the present study are 1) to develop a device to The goals of the present study are 1) to develop a device measure cellular respiration based on scanning electrochemical to measure cellular respiration based on scanning microscopy (SECM), 2) to develop a system to analyze gamete electrochemical microscopy (SECM), 2) to develop a system to analyze gamete integrity using optical coherence integrity using optical coherence tomography (OCT), 3) to establish tomography (OCT), 3) to establish a evaluation system for a evaluation system for oocyteand embryo quality using OCT and oocyte and embryo quality using OCT and SECM, and 4) to SECM, and 4) to apply the measuring device and diagnostic system apply the measuring device and diagnostic system to clinical to clinical fertility treatments on a trial basis. To achieve these goals, fertility treatments on a trial basis. To achieve these goals, we developed a cellular respiration and gamete integrity we developed a cellular respiration and gamete integrity measurement system based on SECM and OCT. This system could measurement system based on SECM and OCT. This system measure the respiratory activity and OCT signals of a single oocytecould measure the respiratory activity and OCT signals of a single oocyte and embryo, such as cattle and mouse, all with and embryo, such as cattle and mouse, all with high reproducibility.high reproducibility. Appealing point：We are conducting experimental clinical research in assisted Special objectivesreproductive technology. A noteworthy outcome of our research is that we successfully measured, the respiratory activity of a single We are conducting experimental clinical research in oocytesand embryos various mammals including human. This study assisted reproductive technology. A noteworthy outcome of added momentum to the effort to establish a diagnostic system for our research is that we successfully measured, the respiratory activity of a single oocytes and embryos various evaluation of oocyteand embryos quality. mammals including human. This study added momentum to the effort to establish a diagnostic system for evaluation of Yamagata UniversityGraduate School of Science and Engineering oocyte and embryos quality. Research Interest ：Reproductive BiologyYamagata University Graduate School of Science and Engineering E-mail ：abeh@yz.yamagata-u.ac.jpResearch InterestTel ：+81-238-26-3361Reproductive Biology Biomedical EngineeringFax：+81-238-26-3177E-mail ・ abeh@yz.yamagata-u.ac.jpTel ・ +81-238-26-3361HP ：http://abe-labo.yz.yamagata-u.ac.jp/Fax ・ +81-238-26-3177HP・http://abe-labo.yz.yamagata-u.ac.jp/Fabrication of nano- and micro-structures using atmospheric pressure plasmasFabrication of nano-and micro-structures using atmospheric pressure plasmasProfessor Tadahiro AitaProfessorTadahiro Aita Development of Diagnotic System for Embryo and Oocyte Quality Using SECM and OCTDevelopment of DiagnoticSystem for Embryo and OocyteQuality Using Professor Hiroyuki AbeSECM and OCT Professor Hiroyuki Abe
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