/ oitar%l046audeRH2Sガガスス100FFeerrrroocceenneeMolecular assembler with redox activityThe aggregate collapses and releases the contents806040blankCu-HApNi-HApCo-HApCa-HApZn-HApFe-HApAl-HAp2002Adsorptionofhydroxyapatitesmodifiedwithvariousmetalcationsforhydrogensulfidegas.Exposure period / hbehavior・Functional DDS carrier・Sustained release capsules for drugs, fragrances, etc.・New reaction site of enzyme27手手動動型型気気体体採採集集器器検検知知管管ササンンププリリンンググババッッググFeOther synthesized functional ferrocene molecules.Mediator-containing typeCoenzyme (ferrocenylNAD+)Biological membrane-affinity type (bisprenyldiphosphate type ferrocene)Stimulus-responsive low molecular weight gelatorIllustrationAstarch-reinforcedcalciumphosphatepaste,whichcanbedeformedoutofourbodyandsetinphysiologicalconditions.Schematicimageofanexaminationforgasadsorptionabilityofasample.apatiteBone-likeontitaniumwhichweresubjectedtochemicalandheat-treatments,aftersoakinginasimulatedbodyfluid.AppearanceofHApdiscsmodifiedwithCu(II)beforeandafterexposureofH2S.depositedEnzyme TechnologyStimulus-responsive ferrocene-crown ether surfactantEnzyme reaction in vesicleContent：ContentWeareinvolvedindevelopmentofnovelfunctionalmaterials We are involved in development of novel functional basedoninorganicsolid,suchas…materials based on inorganic solid, such as…1)Hardtissue-repairingmaterials:Chemicalmodificationofa1) Hard tissue-repairing materials: Chemical modification of a substrateorcoatingofcalciumphosphatesonasubstratetosubstrate or coating of calcium phosphates on a substrate to promote new bone formation in orthopedic or dental promotenewboneformationinorthopedicordentaldefectsinourdefects in our bodies.bodies.2) Environmental purification materials: Specific adsorption 2)Environmentalpurificationmaterials:Specificadsorptionandand removal of odorants, toxic gases and virus, etc.removalofodorants,toxicgasesandvirus,etc.3) Nanostructural materials: Excellent properties for energy 3)Nanostructuralmaterials:Excellentpropertiesforenergyconversion or catalytic reaction. (Ex. inorganic oxide conversionorcatalyticreaction.(Ex.inorganicoxidenanotubes)nanotubes)Wehavefocusedourinterestsondevelopingthesematerialsvia We have focused our interests on developing these materials via ways under mild conditions, which can reduce waysundermildconditions,whichcanreduceenvironmentalload.environmental load .Appealing point：Special objectivesIndustrial-academic collaboration is welcomed.Our goal is development of products closely related to our lives. Industrial-academic collaboration is welcomed.My advantage is to provide even already existing materials with Our goal is development of products closely related to our high added-value. lives. My advantage is to provide even already existing materials Yamagata UniversityGraduate School of Science and Engineering with high added-value. Research Interest ：Inorganic chemistry, CeramicsYamagata University Graduate School of Science and Engineering E-mail ：t-kawai@yz.yamagata-u.ac.jpResearch InterestTel ：+81-238-26-3107Inorganic chemistry, CeramicsFax：+81-238-26-3107E-mail ・ t-kawai@yz.yamagata-u.ac.jpTel ・ +81-238-26-3107Fax ・ +81-238-26-3107ContentContent：Stimulus-responsive ferrocene-crown ether surfactant self- Stimulus-responsive ferrocene-crown ether surfactant self-assembles in aqueous solution to form supramolecules. Due to the assembles in aqueous solution to form supramolecules. Due free rotation of the cyclopentadienyl ring of ferrocene, it usually to the free rotation of the cyclopentadienyl ring of ferrocene, takes formation of anti type in a stable form and a sandwiched syn it usually takes formation of anti type in a stable form and a type in the presence of cations, so that the former forms a vesicle-sandwiched syn type in the presence of cations, so that the former forms a vesicle-like structure and the latter forms a like structure and the latter forms a micelle-like structure. micelle-like structure. Due to the redox activity of ferrocene, it is possible to control the Due to the redox activity of ferrocene, it is possible to control collapse and reformation of the aggregate structure of any of the the collapse and reformation of the aggregate structure of any molecular aggregates by electrochemical redox.of the molecular aggregates by electrochemical redox.We are exploring new functional DDS (drug delivery system) We are exploring new functional DDS (drug delivery carriers that can control the molecular structure, sustained-release system) carriers that can control the molecular structure, sustained-release capsules for drugs and fragrances, and capsules for drugs and fragrances, and possibilities as new reaction possibilities as new reaction sites for enzymes.sites for enzymes.Appealing point：Special objectivesWe are actively working on industry-academia collaboration. We have succeeded in the developing biodiesel fuel manufacturing We are actively working on industry-academia equipment, andthedeveloping confectionery using rice bran koujicollaboration. We have succeeded in the developing until now, and have reached the market. Our special skill is the biodiesel fuel manufacturing equipment, and the developing confectionery using rice bran kouji until now, and have ability to carry out an organic synthesis and enzymatic reactions.reached the market. Our special skill is the ability to carry out an organic synthesis and enzymatic reactions.Research Field : Biochemical Eng.Speciality: Organic Synthesis Yamagata University Graduate School of Science and Engineering E-mail：kijima@yz.yamagata-u.ac.jpResearch FieldBiochemical Eng.Tel ：+81-238-26-3127SpecialityOrganic Synthesis Enzyme TechnologyFax：+81-238-26-3413E-mail ・ kijima@yz.yamagata-u.ac.jpHP ：http://acebe.yz.yamagata-u.ac.jp/laboratory/biochemistry/Tel ・ +81-238-26-3127Fax ・ +81-238-26-3413organic/labo_011/HP・http://acebe.yz.yamagata-u.ac.jp/laboratory/biochemistry/organic/labo_011/Development of highly functional inorganic materials under mild conditionsDevelopment of highly functional inorganic materials under mild conditionsAssociate Professor Takahiro KawaiAssociate Professor Takahiro KawaiDevelopment of highly functional amphipathic molecules with controllable molecular structureDevelopment of highly functional amphipathic molecules with controllable AssociateProfessor Tatsuro KijimaAssociate Professor TatsuroKijimamolecular structure
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