OOHOOOOOOOOOnm.OHOOHOHOHOHOHOHOHOHOHOHOHOHHyper-branchedpolymersun lightDevelopment of a new electron transportsystemStimulation responsiveGeneral-purposePolymer(Eval)EDTAox[Ru(bpy)₃]²EDTA[Ru(bpy)₃]³⁺[Ru(bpy)₃]²⁺Heart -lungmachine Artificial bloodvesselDrug Delivery System (DDS)Excited state*[Ru(bpy)₃]²⁺DrugDrug releasegel-(V2+)nElectronTransfergel-(V+)ngel-(V2+)nStrage28Ourgoalistodevelopanoveldrugforrespiratorydiseases,pneumonia,pulmonaryfibrosis,andchronicobstructivepulmonarydisease(COPD)usinganovelsurfactantprotein,SCGB3A2.stimulationContent：ContentOurgoalistounderstandthemechanismoflungdevelopmentand Our goal is to understand the mechanism of lung respiratorydiseasesfordevelopinganoveldrugtohelppatientswithdevelopment and respiratory diseases for developing a novel respiratorydistresssyndromeandrespiratorydiseases.Becauseandrug to help patients with respiratory distress syndrome and increasingnumberofpeopleareaffectedbyrespiratorydiseasesrespiratory diseases. Because an increasing number of people are affected by respiratory diseases worldwide, with worldwide,withincreasingmorbidityandmortalityrates.increasing morbidity and mortality rates. Wefocusontherolesofasurfactantprotein,Secretoglobin We focus on the roles of a surfactant protein, (SCGB)3A2inlungdevelopmentandrespiratorydiseases.WehaveSecretoglobin (SCGB)3A2 in lung development and alreadyrevealedthat1)SCGB3A2promotesbranchingofbronchirespiratory diseases. We have already revealed that 1) SCGB3A2 promotes branching of bronchi and maturation of andmaturationoflung(AmJRespirCritCareMed.2008),2)lung (Am J Respir Crit Care Med. 2008), 2) SCGB3A2/SCGB3A2/UGRP1suppressesallergicairwayinflammation(AmJUGRP1 suppresses allergic airway inflammation (Am J RespirCritCareMed.2006)and3)SCGB3A2suppressesfibrosisRespir Crit Care Med. 2006 ) and 3) SCGB3A2 suppresses (JBiolChem.2011,BMCPulmMed.2015.).Inourprojects,manyfibrosis (J Biol Chem. 2011, BMC Pulm Med. 2015.).In our projects, many techniques are used as follows; cell techniquesareusedasfollows;cellengineering,molecularengineering, molecular biological technique, animal study, biologicaltechnique,animalstudy,pathologicalandphysiologicalpathological and physiological techniques. techniques.Appealingpoint：Special objectivesSCGB3A2hasapotentialtoimprovesystemicallergicreactions.WewillsolvethemysteryofSCGB3A2andcontributeto"Ensure SCGB3A2 has a potential to improve systemic allergic reactions. We will solve the mystery of SCGB3A2 and healthylivesandpromotewell-beingforallatallages"inSDG3.contribute to “Ensure healthy lives and promote well-being for all at all ages” in SDG3.Yamagata UniversityGraduate School of Science and Engineering Research Interest ：molecular biology, genetic Yamagata University Graduate School of Science and Engineering engineering , physiologyResearch InterestE-mail ：kurotanir@yz.yamagata-u.ac.jpmolecular biology, genetic engineering , physiologyTel ：+81-238-26-3365E-mail ・ kurotanir@yz.yamagata-u.ac.jpFax：+81-238-26-3365Tel ・ +81-238-26-3365Fax ・ +81-238-26-3365HP ：http://kurotani-lab.yz.yamagata-u.ac.jpHP・http://kurotani-lab.yz.yamagata-u.ac.jpContent：ContentDevelopment of newbiocompatiblematerials：In our lab. we Development of new biocompatible materials: In our lab. we have studied on the development of new biocompatible materials by have studied on the development of new biocompatible materials the methods of precision synthesis ( living radical polymerization, by the methods of precision synthesis (living radical Click reaction, etc.) from hyper-branched polymer ( polyglycidol, polymerization, Click reaction, etc.) from hyper-branched polymer ethylene-vinylalcoholcopolymer etc.).( polyglycidol, ethylene-vinylalcohol copolymer etc.).Construction of stimulation responsible drug delivery system: Construction of stimulation responsible drug delivery In order to reduce the side effects of method of drug treatment , we system:In order to reduce the side effects of method of drug have challenged the construction of new drugadministration systemtreatment, we have challenged the construction of new drug （stimulation responsible drug delivery system）. As a core material administration system （stimulation responsible drug delivery system）. As a core material the hyper-branched polymer the hyper-branched polymer ( polyglycidol) was selected , and (polyglycidol) was selected, and poly(N-isopropylacrlamide) as a poly( N-isopropylacrlamide) as a stimulation responsible part and stimulation responsible part and polyethylene glycohol as a polyethylene glycoholas a biocompatible unit were used. We biocompatible unit were used. We synthesized the polymer having synthesized the polymer having three parts and are evaluating of the three parts and are evaluating of the polymers obtained.polymers obtained. Development of a new electron transport system: We Development of a new electron transport system: We created a created a new electron transport system similar to photosynthesis new electron transport system similar to photosynthesis using using viologen polymers which are useful an electron carriers, viologen polymers which are useful an electron carriers, and are and are trying to apply the system to various electron reactions.trying to apply the system to various electron reactions. Appealing point：Sophisticated organic and polymer synthetic skill.Creation of biomimetic system. Sophisticated organic and polymer synthetic skill. Creation of biomimetic system.Yamagata UniversityGraduate School of Science and Engineering Research Interest ：Polymer ChemistryYamagata University Graduate School of Science and Engineering Organic ChemistryResearch InterestE-mail ：riki@yz.yamagata-u.ac.jpPolymer Chemistry Organic ChemistryTel ：+81-238-26-3087E-mail ・ riki@yz.yamagata-u.ac.jpFax：+81-238-26-3177Tel ・ +81-238-26-3087HP ：rikiya-lab.yz.yamagata-u.ac.jp/Fax ・ +81-238-26-3177HP・rikiya-lab.yz.yamagata-u.ac.jp/Special objectivesDevelopment of a novel drug for respiratory diseases.Associate Professor Reiko KurotaniAssociate ProfessorReiko KurotaniAssociate Professor Rikiya SatoAssociate Professor RikiyaSatoDevelopment of a novel drug for respiratory diseases.Surfactant protein is a useful a drug for respiratory diseases !?Developments of Organic Functional MaterialsDevelopments of Organic Functional Materials
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