esoculgsaldoolB)Lm/gn( nilusni am)Ld/gm543210( 01P325532104Time (min)Fig. 2Effect of the stimulation on plasma insulin4Time (min)Mechanical loading Cell burst AfterYamagata UniversityGraduate School of Science and Engineering Research Interest ：Biomaterials, Biology, Regenerative medicineE-mail ：sathiga@yz.yamagata-u.ac.jpYamagata University Graduate School of Science and Engineering Research InterestTel ：+81-238-26-3395Biomaterials, Biology, Regenerative medicineFax：+81-238-26-3395E-mail ・ sathiga@yz.yamagata-u.ac.jpTel ・ +81-238-26-3395Fax ・ +81-238-26-33953475Mean±SD706560Fig. 1Effect of the electrical stimulation on blood glucoseTable1Effect of the stimulation on glucose uptakeBeforeGlucose infusion rate (mg/kg/min)Plasma insulin(ng/mL)These data were obtained with euglycemicclamp method.Insulin infusion rate: 12.5 mU/kg/min. Mean±SD.12.9 ±1.621.6 ±7.4Mechanism behind this matrix mineralizationSoft tissue and cells manipulation in vitroMean±SDStimulationDuring15.3 ±1.714.7 ±2.019.0 ±7.322.0 ±11.2(Fig.2).Biomedical EngineeringofthetissuebehavioritsandEncapsulation of MC3T3 cells in hydrogel beads 0 day3 day6 dayContentContent：Lifestylediseaseisoneofsocialissues,andthereisagrowing Lifestyle disease is one of social issues, and there is a growing needformoreeffectivetreatmentsforimpairedglucosetoleranceneed for more effective treatments for impaired glucose tolerance anddyslipidemia.and dyslipidemia. Theglucoseandlipidmetabolismarecontrollednotonlyby The glucose and lipid metabolism are controlled not only by hormonebutalsobynervoussystem.Therefore,thepresentstudyhormone but also by nervous system. Therefore, the present intendedtodevelopmentofanovelmethodforartificialcontrolofglucoseandlipidmetabolismwithelectricalstimulationofstudy intended to development of a novel method for artificial peripheralsympatheticnerve.control of glucose and lipid metabolism with electrical stimulation Wepreviouslyconductedtheelectricalstimulationofperipheralof peripheral sympathetic nerve.sympatheticnervefascicleinnormal-chow-fedratsandobservedthe We previously conducted the electrical stimulation of peripheral temporalbloodglucosereduction(Fig.1)andthelittlechangeinsympathetic nerve fascicle in normal-chow-fed rats and observed Inaddition,wefoundthatplasmainsulinlevelthethe temporal blood glucose reduction (Fig. 1) and the little change stimulationinthenormal-chow-fedratsenhancesglucoseuptakein plasma insulin level (Fig. 2). In addition, we found that the (Table1).stimulation in the normal-chow-fed rats enhances glucose uptake (Table 1). Appealing point：ThisresearchprojectistodevelopnovelmedicaldeviceswhichSpecial objectivesenabletocontrolofenergymetabolism. This research project is to develop novel medical devices which enable to control of energy metabolism. Yamagata UniversityGraduate School of Science and Engineering Research Interest ：MetabolismYamagata University Graduate School of Science and Engineering E-mail ：d_sato@yz.yamagata-u.ac.jpResearch InterestTel ：+81-238-26-3357Metabolism Biomedical EngineeringFax：+81-238-26-3357E-mail ・ d_sato@yz.yamagata-u.ac.jpTel ・ +81-238-26-3357Fax ・ +81-238-26-3357ContentContent： In the field of tissue engineering it is important to understand Inthefieldoftissueengineeringitisimportanttounderstandthethe developmental behavior of the tissue and its surrounding developmentalsurroundingenvironment.environment. So,ourgoalistounderstandthetissuespecificmechanical So, our goal is to understand the tissue specific mechanical environmentthatneedfortissueproliferationandgrowth.Andalsoenvironment that need for tissue proliferation and growth. And wewilltrytoevaluatetheparticularcellsandormoleculesthatreactalso we will try to evaluate the particular cells and or molecules withthismechanicalenvironment.that react with this mechanical environment.Inourlaboratory,wearemainlyworkwithhydrogelandassample In our laboratory, we are mainly work with hydrogel and as weusebones,varietyofsofttissue(salivarygland,kidney,pancreasandlungs)fromembryonicmouse.sample we use bones, variety of soft tissue (salivary gland, kidney, pancreas and lungs) from embryonic mouse.Artificial control of energy metabolism via nervous systemMechanical Stimulation In Tissue DevelopmentAssistant Professor Daisuke Sato Assistant ProfessorDaisuke SatoAssistant Professor Gulsan Ara SathiAssistant ProfessorGulsanAra SathiArtificial control of energy metabolism via nervous systemMechanical Stimulation In Tissue Development
元のページ ../index.html#36